Introduction to Climate Change Mitigation and Adaptation

Since the first edition of the handbook, important new research findings on climate change have been gathered. The evidence has further solidified, and the effects have become more visible. Both mitigation and adaptation of climate change are more important than ever before. The handbook in its presently third edition was completely updated and extended in coverage. Climate change is a fact, and aspects of "doing business in climate change” were included alongside scientific evidence on climate change, mitigation technologies – both established and novel – and adaptation measures to provide maximum benefit to its readers. The impacts of climate change have made it into our daily lives. All human beings, in turn, can contribute to the mitigation and adaptation of climate change. Consequently, these topics are discussed in schools, in private settings, in research, and in the business world. We can see solid implications of climate change. The 2020 COVID-19 crisis has paralyzed the entire world almost instantly. Climate change is slower and subtler, but even more severe in its potential and factual consequences, where no "fix” like a vaccination exists to return to the previous state. This handbook is more necessary than ever before. Over the last several million years, there have been warmer and colder periods on Earth, and the climate fluctuates for a variety of natural reasons, as data from tree rings, pollen, and ice core samples have shown. However, human activities on Earth have reached an extent that they impact the globe in potentially catastrophic ways, in terms of magnitude and irreversibility. Mitigation and adaptation are the two principal routes of our responses to climate change, and they, in fact, can be best achieved collectively by world citizens, scientists and nonscientists, in our daily lives. This chapter is an introduction to climate change and the handbook in its third edition. Current state of the arts of climate change mitigation and adaptation approaches are discussed. © Springer Nature Switzerland AG 2022. All rights are reserved.

Strategic flexibility or persistence? Examining the survival path of export enterprises under COVID-19

Purpose The rising uncertainties in the macroeconomic environment exacerbate the challenges firms face in the export market. This study aims to explore which strategy is suitable for export enterprises to develop sustainably under COVID-19. Design/methodology/approach Based on the sample data of China's A-stock listed manufacturing firms from 2010 to 2020, this study applies a survival analysis method to explore the impact of strategic flexibility on export firm survival. Furthermore, this study uses the difference-in-difference model to test the relationship between strategic flexibility and firms' profits in the context of the pandemic. Findings The results show that strategic flexibility can increase firms' survival time, improving dynamic production and innovation capabilities, which is favorable for their sustainable development. Meanwhile, after the spread of COVID-19, firms with strategic flexibility have higher profits than those without. This influence mechanism mainly involves exploring new markets that can improve the company revenue and the coordination capabilities of the supply chain;this reduces corporate costs. Originality/value This study expands relevant research on the factors affecting the survival of export enterprises and supplements research on the economic consequences of firms' strategic flexibility;this also enriches the dynamic capability theory. Additionally, it provides important implications for firms to enhance strategic flexibility and recommends government implementation of policies that encourage the domestic sales of commodities originally produced for exports under COVID-19.

DNA-Functionalized Ti3C2Tx MXenes for Selective and Rapid Detection of SARS-CoV-2 Nucleocapsid Gene

Coronavirus disease 2019 (COVID-19) is an emerging human infectious disease caused by severe acute respiratory syndrome 2 (SARS-CoV-2, initially called novel coronavirus 2019-nCoV) virus. Thus, an accurate and specific diagnosis of COVID-19 is urgently needed for effective point-of-care detection and disease management. The reported promise of two-dimensional (2D) transition-metal carbides (Ti3C2Tx MXene) for biosensing owing to a very high surface area, high electrical conductivity, and hydrophilicity informed their selection for inclusion in functional electrodes for SARS-CoV-2 detection. Here, we demonstrate a new and facile functionalization strategy for Ti3C2Tx with probe DNA molecules through noncovalent adsorption, which eliminates expensive labeling steps and achieves sequence-specific recognition. The 2D Ti3C2Tx functionalized with complementary DNA probes shows a sensitive and selective detection of nucleocapsid (N) gene from SARS-CoV-2 through nucleic acid hybridization and chemoresistive transduction. The fabricated sensors are able to detect the SARS-CoV-2 N gene with sensitive and rapid response, a detection limit below 10(5) copies/mL in saliva, and high specificity when tested against SARS-CoV-1 and MERS. We hypothesize that the MXenes' interlayer spacing can serve as molecular sieving channels for hosting organic molecules and ions, which is a key advantage to their use in biomolecular sensing.

Prevention and Control Strategy for Multi-group Epidemics Based on Delay and Isolation Control

Aiming at the prevention and control of multi-group epidemics, the dynamic model of disease transmission is established, and an optimal delay and isolation strategy is proposed. The control variables in the model represent the strength of various measures taken to block and isolate contact between groups. The optimal control problem is solved by Pontryagin maximum principle and the corresponding numerical iterative algorithm is given. The results show that the delay and isolation control strategy can effectively control the epidemic of infectious diseases while minimizing the cost of infectious diseases. The outbreak of the COVID-19 in 2020 is a serious threat to people's lives and health. It is because of the timely adoption of delay and isolation control strategy of "early detection and early isolation" and "joint-prevention and joint-control", China took the lead in the fight against the epidemic situation and made an example for the whole world.

A cross-sectional survey on information access through hospital's official account on new media and its association with antenatal care knowledge and health behaviors of pregnant women under COVID-19 epidemic

Objective To explore the association between accessing antenatal care information through hospitals' official new media accounts and antenatal care knowledge and individual prevention behavior under COVID-19 epidemic, and to provide evidence for improving the emergency plan for maternity health care services in China under public health emergencies. Methods The online survey was conducted from Feb 5th to Mar 1st, 2020, at the peak of the COVID-19 epidemic in China. Approaches of accessing antenatal care information, COVID-19 related antenatal care knowledge and individual prevention behavior was collected via cross-sectional design. Results A total of 1 936 valid questionnaires were obtained from 21 provinces, autonomous regions and municipalities. Under the COVID-19 epidemic, 75.4% of the pregnant women reported they got institutional service and health education information from hospitals' official new media accounts such as WeChat and Weibo. Multivariate Logistic analysis showed that pregnant women who received information from official accounts of new media had higher scores of COVID-19 relevant antenatal care knowledge (aOR=1.36, 95%CI:1.08-1.71, P<0.01)and individual prevention behaviors(aOR=1.46, 95%CI:1.18-1.82, P<0.01) than those who obtained information from other sources. Conclusion The access to antenatal care knowledge via hospitals' official social media accounts was associated with better antenatal care knowledge and individual prevention behaviors among pregnant women. Under major public health emergency, it is suggested for health institutions to disseminate antenatal health care information via hospitals' official accounts in new media like Wechat and Weibo. Appropriate training should be developed to ensure the quality of health education and service provision in official new media accounts. © 2021, Editorial Department of Fudan University Journal of Medical Sciences. All right reserved.

Prediction of potential therapeutic drugs against SARS-CoV-2 by using Connectivity Map based on transcriptome data.

OBJECTIVE: Transcriptome data related to severe acute respiratory syndrome-related coronavirus 2 (a novel coronavirus discovered in 2019, SARS-CoV-2) in GEO database were downloaded. Based on the data, influence of SARS-CoV-2 on human cells was analyzed and potential therapeutic compounds against the SARS-CoV-2 were screened. MATERIALS AND METHODS: R package "DESeq2" was used for differential gene analysis on the data of cells infected or non-infected with SARS-CoV-2. The "ClusterProfiler" package was used for GO functional annotation and KEGG pathway enrichment analysis of the differentially expressed genes (DEGs). A protein-protein interaction (PPI) network of the DEGs was constructed through STRING website, and the key subset in the PPI network was identified after visualization by Cytoscape software. Connectivity Map (CMap) database was used to screen known compounds that caused genomic change reverse to that caused by SARS-CoV-2. RESULTS: By intersecting DEGs in two datasets, a total of 145 DEGs were screened out, among which 136 genes were upregulated and 9 genes were downregulated in SARS-CoV-2-infected cells. Functional enrichment analyses revealed that these genes were mainly associated with the pathways involved in viral infection, inflammatory response, and immunity. The CMap research found that there were three compounds with a median_tau_score less than -90, namely triptolide, tivozanib and daunorubicin. CONCLUSIONS: SARS-CoV-2 can cause abnormal changes in a large number of molecules and related signaling pathways in human cells, among which IL-17 and TNF signaling pathways may play a key role in pathogenic process of SARS-CoV-2. Here, three compounds that may be effective for the treatment of SARS-CoV-2 were screened, which would provide new options for improving treatment of patients infected with SARS-CoV-2.